Helaas is deze vacature inmiddels waarschijnlijk verlopen
Sluitingdatum 25 PhD Student
- Salary : 2495 to 3196 euro
- temporary contract
Your challenge
In the Dementia Discovery Group we use induced pluripotent stem cell (IPSC)-derived brain cells to study the early processes that drive Alzheimer’s Disease (AD) pathogenesis, with the aim of translating basic findings to novel therapeutics. We have recently shown that changes in cholesterol metabolism causes the accumulation of toxic Alzheimer proteins (e.g. Abeta and Tau). In this PhD project, the goal is to uncover how cholesterol metabolism is altered in AD, and how it contributes to early pathogenesis. The project will combine iPSC disease-modeling, lipid- and biochemical mapping together with the establishment of novel state-of-the art neuronal cholesterol reporter assays to understand these early disease steps, and to define -and test- novel (pre)clinical cholesterol-targeting interventions for AD.In the Dementia Discovery Group, you will:
- Use iPSC-derived neurons and astrocytes to understand how AD risk genes affect inter- and intracellular cholesterol transport;
- Develop novel assays to monitor cholesterol flux in human brain cells suitable for high-throughput (drug) screening;
- Participate in team research to develop cholesterol-targeting therapeutic approaches for the treatment of Alzheimer’s disease.
Your profile
We are looking for a researcher with the following expertise and experience:- Master degree in neuroscience, biomedical sciences or biology;
- Experience with biochemical and/or cell-biological techniques;
- Affinity or experience with lipid metabolism and/or assay development is an advantage;
- Excellent organizing and communicative skills in English;
- A strong motivation to pursue a career in science.
Your work environment
The Amsterdam UMC Alzheimer Center is an internationally recognized clinic for patient care and scientific research in the field of dementia. Our mission is to make dementia treatable and eventually curable. With a staff of over 75 employees we are part of the department of neurology of the Amsterdam UMC, the largest academic hospital in the Netherlands. We are convinced that by uniting scientific research with patient care, we can make progress in the battle against dementia. For more information please visit our(Dutch).
Working at Amsterdam UMC means working in an inspiring and professional environment where developing one`s talents and academic skills are encouraged. We offer you ample opportunity for development, deepening and broadening, additional training, and a place to grow!
We offer
Salary Scale PHD: 2495 tot 3196 euro gross when employed full-time (depending on qualifications and experience).The monthly wage will increase yearly to the maximum salary in the fourth year of 3,196 € gross per month.
In addition, we offer:
- Additional benefits include an 8.3% end-of-year bonus and 8.0% holiday pay.
- The opportunity to follow further training and development.
- Pension is accrued at the ABP. VUmc contributes a large part of the premium (70%).
- In addition to excellent accessibility by public transport, we reimburse 75% of your OV travel costs (commuting costs).
For more information about our employment conditions, please visit our
.
For Dutch citizens it is mandatory to provide a VOG (Verklaring Omtrent Gedrag). Foreign citizens need to provide comparable police clearing certificates.
Additional information
We ask the candidates to expect the first job interview appointments in August 2021. The earliest expected starting date of the position is from September 1st, 2021.Information and application
Don’t hesitate to call us!If you’re interested about this position, you can contact
Rik van der Kant
, via telephone number 020 444 8704.If you need more information about the application procedure, contact
Brend de Jong, corporate recruiter
at 020 444 5635.You can apply till 25 July 2021 by using the apply button.
Acquisition based on this vacancy is not appreciated.
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