Helaas is deze vacature inmiddels waarschijnlijk verlopen

Postdoc in vivo/molecular biology

Patients with brain tumors have a poor prognosis. These patients are in urgent need of improved treatment strategies where efficacy and toxicity should be optimally balanced. To study this, we have the following vacancy.

Postdoc in vivo/molecular biology
Copy Link

Aantal uur:
36 uur per week

Werklocatie:
Locatie VUmc

Contractvorm:
bepaalde tijd

Salaris:
€ 2.986 - € 4.707

Reageer tot en met:
17 juni 2022
Reageer binnen
5
dag(en)
Wat
ga
je onderzoeken?
Activating kinases are frequently present in tumor that originate or metastasize to the brain. In this project we will optimally adapt therapies to multiple activated kinases. For this, we have generated a target predictor for each small molecule inhibitor based on the drug and target structures. This enables us to match bioactivity (target) fingerprints to personalized vulnerabilities aimed to generate more effective therapies. Within the project, we aim to test existing but also de novo generated kinase inhibitors for their effect against brain tumors. Targeting multiple targets comes with the cost of potential toxic effects. In addition to the target predictor, we have generated a predictor for selecting optimal target-combinations with limited adverse events. Our approach will guide us to reach an optimal effectivity to toxicity ratio for existing and new small molecules.

Vragen over deze functie?
Tanja Hart
Recruitment adviseur
Stel een vraag
Om verder te kunnen gaan, voer gegevens in bij de gemarkeerde velden.
Om verder te kunnen gaan, voer gegevens in bij de gemarkeerde velden.
Sluiten
Annuleren
Versturen
Wat
ga
je doen?
You will work on the mechanisms that underly effective anti-cancer kinase inhibitors and delineate them by performing drug screens aimed at individual targets followed by in vivo validation of the results. Pharmacodynamic, pharmacokinetic and blood brain barrier studies of existing and de novo generated drugs will be performed in collaboration with two companies. You will also work on reporter systems for real time assessment therapy resistance.

If you have not yet obtained a PhD, there is the possibility to obtain a PhD on this research project.
Wat
neem
je mee?
You are a highly motivated and ambitious candidate with a master/PhD degree in biomedical sciences/molecular biology in the oncology domain or related.

In addition you meet the following requirements:
You are strongly committed and not afraid of working within technically challenging environment; you are experienced in primary cell culture and in animal studies, which can take up to 40% of your time in this project; you have affinity with modern molecular biology and next-generation techniques (CRISPR technology, next-generation sequencing, mass cytometry); you have the desire to facilitate translation of your results into the clinic; you are able to function well in a team as well as independently, possess good communication skills and are comfortable with an international cross-disciplinary environment; you are competent in English and proficient in writing; you have affinity with writing protocols, reporting and registration. For international applicants, an English proficiency test score or a recommendation by a referee is desired.

Wat
bieden
we jou?

• A contract for one year (12 months) with the intention to extend for another 24 months.
• Besides a good basic salary, you will also receive an 8.3% year-end bonus and 8% holiday allowance. Calculate your net salary

.

• Free and unlimited access to our online learning environment GoodHabitz.
• Pension accrual with ABP, of which we pay 70% of the premium.
• Reimbursement of 75% of your public transport costs. Would you rather travel by bike? Then we have a good bicycle scheme.
• An active personnel association and the Young Amsterdam UMC association, both of which organise fun (sports) activities and event

Waar ga je
werken
?
You will work in a collaborative project within academia (Dr. Westerman) together with industry partners, connected to international networks with Top European Institutions. The strength of the institute lies in opportunity to have interdisciplinary interactions with researchers and clinicians/MDs to share expertise and ideas. Working at Amsterdam UMC means working in an inspiring and professional environment where developing one`s talents and academic skills are encouraged. The institute is located at the campus at the South part of Amsterdam providing easy access to downtown Amsterdam as well as to local and international travel. Amsterdam offers a unique cultural environment. We offer you ample opportunity for development, deepening and broadening, additional training, and a place to grow.

De cultuur is open en de samenwerking over het algemeen laagdrempelig. Bovendien streven we naar gelijke kansen voor iedereen. Dat betekent dat er ruimte is voor een ieders cultuur, afkomst, ideeën en creativiteit.

.
Wat kun je
verwachten
?
Een baan in onze prachtige hoofdstad
Werken bij dé favoriete werkgever in de zorg (intermediair 2021)
Alle collega's hebben hetzelfde doel: bijdragen aan de zorg voor morgen
Er is ruimte voor ontplooiing, verdieping en verbreding van je kennis
Een actieve personeelsvereniging die leuke activiteiten organiseert en korting op producten en diensten voor jou regelt
Amsterdam UMC innoveert continu, dat vraagt om een flexibele instelling van iedereen
Twee grote locaties, goed voor je stappenteller!
Je hebt meer dan 15000 collega’s die je niet allemaal persoonlijk zult leren kennen
Het verhaal van Amsterdam UMC
Bekijk de video’s en leer meer over onze organisatie
Amsterdam UMC
Tulp
Verpleegkundige visie
Laten we kennis maken
During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.
For more information about this position, you can contact
Dr. Bart Westerman
, associate professor and PI, via
0031 (0)6 255 776 43
or via
,
If you need more information about the application procedure, contact
Tanja Hart
, corporate recruiter at
0031 (0)6 21603178 or via
.
Acquisition based on this vacancy is not appreciated.
For Dutch citizens it is mandatory to provide a VOG (Verklaring Omtrent Gedrag). Foreign citizens need to provide comparable police clearing certificates.

Deze vacatures vind je misschien ook leuk

meer...



Meer vacatures van Amsterdam Umc