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Postdoc 'PERISCOPE project - Immunity against pertussis

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About the position

• 36 hours per week
• Temporary
• 1 year and 3 months
• Salary scale 10
• min € 2911 - max € 4615 gross per month for full-time employment
• Deadline: 3 May 2021

#weareradboudumc, what about you?

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Within the immunology field, the Radboudumc coordinates a large European (IMI) project: PERISCOPE . In this project, we study immunity against pertussis (or whooping cough). We are looking for a postdoc to join our project that uses data-driven biostatistical modelling, bioinformatics and...

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Job description

Within the immunology field, the Radboudumc coordinates a large European (IMI) project:

. In this project, we study immunity against pertussis (or whooping cough). We are looking for a postdoc to join our project that uses data-driven biostatistical modelling, bioinformatics and machine-learning methods to map variation in the immune response to pertussis vaccination and infection with the aim to identify biomarkers of protection and immunological persistence.

Pertussis is a highly transmissible acute respiratory disease caused by the bacterium Bordetella pertussis, which has re-emerged as a serious public health issue despite high vaccine coverage in many countries. At present, multiple pertussis vaccines are in use, which differ both in composition as well as the type of immune response that is induced. Within PERISCOPE, a range of human clinical studies have been performed to understand these differences and to establish an immunological framework for developing the next generation of pertussis vaccines. These studies include controlled human infection studies and vaccination studies in various populations, including pregnant women, infants, children, adolescents and adults (see Longitudinal samples have been collected within these studies for analysis of immunological parameters, including antibodies, B-cells and T-cells, but also bulk and single-cell gene expression data.

The key

tasks and responsibilities

for this project are:

• Examine the development and persistence of immune response parameters against pertussis in different intervention groups.
• Correlate immunological responses with various parameters, including infection endpoints and prior vaccination status.
• Perform statistical analyses of immunological data to describe the longitudinal effects of infection or vaccination on immunity and to compare vaccination strategies.

Prepare research reports in the form of publications, presentations and progress reports.
Communicate with other members of the research team on a weekly basis.
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The Centre for Molecular and Biomolecular Informatics (CMBI) fosters a lively, international and interactive scientific culture that aims to have a significant impact on health care and to obtain mechanistic insights into life by applying new and existing methods in the analysis of biomedical...

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Department

(CMBI) fosters a lively, international and interactive scientific culture that aims to have a significant impact on health care and to obtain mechanistic insights into life by applying new and existing methods in the analysis of biomedical data. We strive for excellence through innovation and through intense collaboration to identify the relevant research questions and design follow up experiments

Laboratory of Medical Immunology (LMI)

Directly involved in this project is the LMI, which is embedded within the Department of Laboratory Medicine and the Radboud Center for Infectious Diseases and performs core immunological patient diagnostics within the Radboudumc. LMI research is focused on the regulation of the immune system, with a particular focus on immunity to infectious diseases. Members of the CMBI and the LMI collaborate closely together in this project learning from each other about immunology and computational methodology.

Radboudumc

Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have

a significant impact on healthcare
. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our
and what
means.
would be happy to tell you about it.

#weareradboudumc

.
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We are looking for a postdoc with the ability and enthusiasm to learn new methods and skills. You have a pro-active attitude and excellent communication skills. Besides that, you are able to cope with stress and show some perseverance. You have: A PhD in immunology with a proven interest in the...

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Profile

We are looking for a postdoc with the ability and enthusiasm to learn new methods and skills. You have a pro-active attitude and excellent communication skills. Besides that, you are able to cope with stress and show some perseverance. You have:

• A PhD in immunology with a proven interest in the statistical analyses of the data, e.g. in R

or

• A PhD in computational biology/bioinformatics/statistics, with proven interest in immunology

Furthermore:

• Experience with programming, e.g. in R, is preferred.
• Ability to work as part of a team, but also to perform research independently.
• Ability to organise and prioritise own work, work in a project-based manner.

Let's meet

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Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. But there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At...

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Terms of employment

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. But there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together. We provide annual courses, both professional and personal.

• In addition to your monthly salary and an annual vacation allowance of 8%, you will receive an end-of-year bonus of 8.3%.
• If you work irregular hours, you will receive an allowance (47% or 72%) for this.
• As a full-time employee, you are entitled to approximately 168 vacation hours (over 23 days) per year.
• Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
• You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.

In addition to our
, we also offer employees various other
such as childcare and sports facilities. Want to learn more? Take a look at the
.

Apply at

Radboud university medical center
Application procedure
What can you expect when you apply for a job at Radboudumc?
Frequently asked questions
Read the frequently asked questions from applicants and of course the answers.
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ll additional information about the vacancy can be obtained from Prof. Martijn Huynen , Full Professor. Use the Apply button to submit your application.

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Contact

ll additional information about the vacancy can be obtained from
, Full Professor.
Use the Apply button to submit your application.
We would like to receive your application before
3

May 2021.

What else can you expect?

When you join us, we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. You do not have to do anything for this; we will tell you more later. Read more what our

can do for you when moving to the Netherlands, about the application process or view our frequently asked questions.
Recruitment agencies are asked not to respond to this job posting.

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