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Postdoctoral in Stem Cells Organoids Inner ear
Hearing impairment - via Euraxess - 16-08-2022
Naar vacature
Postdoctoral position in Stem Cells – Organoids – Inner ear
Application Deadline: 31/12/2022 17:00 - Europe/London
Contact Details
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CompanyLaboratory of Bioengineering and NanoSciences, LBN, University of Montpellier
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ORGANISATION/COMPANYLaboratory of Bioengineering and NanoSciences, LBN, University of Montpellier
DEPARTMENT
Faculty of Odontology
ORGANISATION TYPE
Research Laboratory
WEBSITE
COUNTRY
France
CITY
Montpellier
POSTAL CODE
34193
STREET
545 avenue du Professeur Jean-Louis Viala
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Please login to use this functionality.ORGANISATION/COMPANY
Laboratory of Bioengineering and NanoSciences, LBN, University of Montpellier
RESEARCH FIELD
Biological sciences
›
Biological engineering
RESEARCHER PROFILE
Recognised Researcher (R2)
APPLICATION DEADLINE
31/12/2022 17:00 - Europe/London
LOCATION
France › Montpellier
TYPE OF CONTRACT
Temporary
JOB STATUS
Full-time
HOURS PER WEEK
40
EU RESEARCH FRAMEWORK PROGRAMME
Interreg
OFFER DESCRIPTION
Hearing impairment is the most frequent human neurosensory deficit. It is mainly caused by the degeneration of neurosensory cells in the cochlea, the auditory portion of the inner ear. The neurosensory cells including the hair cells and the primary auditory neurons can be destroyed by exposure to noise, ototoxic drugs, infection, autoimmune disease, or aging. In mammals including human, these neurosensory cells do not regenerate resulting in a profound and irreversible sensorineural hearing loss. The lack of human otic cell models represents a significant roadblock that has hampered the development of emerging therapeutics for the treatment of hearing loss. Addressing these limitations will serve for the development of novel human inner ear protective and regenerative strategies (Zine et al., Stem Cells 2021 for a recent review).We are looking for a motivated and creative post-doctoral fellow to join the Inner ear Stem Cell Biology Research Lab (
) and study normal and pathological development of the human inner ear using stem cell-derived organoids as a model system.
We recently developed 2D and 3D-based in vitro differentiation systems to generate an enriched population of inner ear sensory cells from human induced pluripotent stem cells via controlled induction and stepwise guidance that mimics the otic in vivo microenvironment. By optimizing this novel model system, we aim at elucidating the mechanisms underlying inner ear sensory cell differentiation and identifying means to promote hair cell protection and regeneration in the human cochlea and opens the door for developing new strategies to cure hearing loss.
The Zine lab is a highly collaborative group with diverse research backgrounds ranging from stem cell biology, neuroscience, and molecular biology. The experimental approaches we are currently using include 2D and 3D-oraganoid culture systems of human pluripotent stem cells, bioengineering, cochlear explants, RNA-seq, 3D imaging/microscopy.
Funding is available for supporting this position for one year renewable up to three years. The application is open until the position is filled. The starting date is flexible.
If interested, please send:
curriculum vitae
,
a description of research accomplishments
and
names of three references
to Dr. Azel ZINE (
), Vice Chair for Laboratory of Bioengineering and Nanoscience at the University of Montpellier, France.
More Information
Offer Requirements
REQUIRED EDUCATION LEVELBiological sciences: PhD or equivalent
REQUIRED LANGUAGES
ENGLISH: Basic
Skills/Qualifications
Hands on experience with induced pluripotent stem cells and 3D stem cell biology is required. Computational skills for RNA-seq and/or single cell data analysis would be an advantageMap Information
Job Work LocationPersonal Assistance locations
Work location(s)
1 position(s) available at
Laboratory of Bioengineering and NanoSciences
France
Montpellier
34193
545 avenue du Professeur Jean-Louis Viala
EURAXESS offer ID: 819069
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