Helaas is deze vacature inmiddels waarschijnlijk verlopen

Postdoctoral researcher in Neuroimmunology

Understanding, and mimicking, the biological effects of the PLCγ2 P522R variant that protect against Alzheimer’s’ disease.

• 36 hours
• Salary : 2911 to 4615 euro
• temporary contract

Your challenge

The Dementia Discovery group in the Center for Neurogenomics and Cognitive Research in Amsterdam (see
) is seeking applications for a Postdoctoral researcher in Neuroimmunology.
The Project: Understanding, and mimicking, the biological effects of the PLCγ2 P522R variant that protect against Alzheimer’s’ disease.
Phospholipase C-gamma-2 (PLCγ2) is a key enzyme involved in immune signaling and lipid metabolism in microglia and macrophages. A genetic hypermorphic variant in PLCγ2, PLCγ2 P522R, protects against Alzheimer’s disease (AD) as well as other dementias through unknown mechanism. The current project aims to understand how PLCγ2 P522R exerts its protective effect for dementia, and how this variant is different from other genetic PLCγ2 variants that cause immune disorders such as PLAID and APLAID. The project will employ gene-edited iPSC-derived microglia and macrophages to study the cell-biological and immunological pathways affected by PLCγ2 variants. As part of a translational program between the CNCR and the Amsterdam UMC

(Prof. Philip Scheltens), the project will also aim to develop reporter assays that will aid future discovery of PLCγ2 P522R-mimicking drugs.

As a postdoctoral researcher your main tasks and responsibilities are:

• Generate, grow and maintain iPSC-derived microglia and macrophages with different PLCγ2-variant genotypes.
• Design and execute targeted in vitro experiment to probe molecular pathways in which PLCγ2 P522R specifically affects immune-cell function.
• Perform broad transcriptomic and lipidomic characterization of iPSC-derived microglia and macrophages with different PLCγ2-genotypes.
• Establish reporter assays that can aid the future discovery of PLCγ2 P522R-mimicking drugs.

Your profile

We are looking for a postdoc with the following qualifications:

• PhD in immunology or neuroscience, with strong knowledge on immune function and signaling;
• Experience with iPSC-derived or primary microglial or macrophage cultures;
• Experience with transcriptomic analysis and/or gene-editing is preferred but not strictly required;
• Excellent organizing and communication skills;
• A strong motivation to pursue a career in science.

Your work environment

The Amsterdam UMC Alzheimer Center is an internationally recognized clinic for patient care and scientific research in the field of dementia. Our mission is to make dementia treatable and eventually curable. With a staff of over 100 employees we are part of the department of neurology of the Amsterdam UMC, the largest academic hospital in the Netherlands. We are convinced that by uniting scientific research with patient care, we can make progress in the battle against dementia. For more information please visit our

(Dutch).
Working at Amsterdam UMC means working in an inspiring and professional environment in which developing one`s talents and skills is encouraged. We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow!

We offer

Salary Scale 10: 2911 tot 4615 euro gross when employed full-time (depending on qualifications and experience).
This monthly wage will increase yearly.

In addition we offer:

• In addition to a good salary, we offer 8.3% end-of-year bonus and 8% holiday allowance.
• Free and unlimited access to the training offer of our online learning environment GoodHabitz.
• Your pension is accrued at The Dutch Pension Fund for government and education employees (ABP). Amsterdam UMC contributes 70% of this scheme.
• We reimburse 75% of your public transport travel costs and also offer a bicycle arrangement.
• For non-Dutch citizens there is an opportunity to receive a 30% tax break. For more information please visit our

.
The current project is funded for two years, but may generate future funds to extend beyond the 2-year project, with the possibility of the postdoctoral trainee to apply for his/her own grants.

For more information about our employment conditions, please visit our
.
For Dutch citizens it is mandatory to provide a certificate of conduct (Verklaring Omtrent Gedrag; VOG).

Information and application

Don’t hesitate to call us!
If you’re interested about this position, you can contact

Rik van der Kant

, via telephone number 020 444 8704.
If you need more information about the application procedure, contact

Brend de Jong, corporate recruiter

at 020-4448704.
You can apply till 28 March 2021 by using the apply button.
Acquisition based on this vacancy is not appreciated.
meer...



Meer vacatures van Vumc