Helaas is deze vacature inmiddels waarschijnlijk verlopen
Postdoctoral researcher Medical Oncology
Amsterdam Umc - 21-01-2022
Naar vacature
Finding regulatory mutations in the non-coding cancer genome of diffuse type gastric cancers
Postdoctoral researcher Medical Oncology
Copy Link
Aantal uur:
32
Specialisme:
Inwendige specialismen
Contractvorm:
bepaalde tijd
Salaris:
€ 2.986 - € 4.707
Reageer tot en met:
13 februari 2022
Reageer binnen
7
dag(en)
Wat
ga
je onderzoeken?
Within the research group of dr. S. Derks at Amsterdam UMC-location VUmc, we take multiple efforts to understand the biology of gastric cancer in order to find better therapies and improve outcome. While large genome and transcriptome studies such as those from The Cancer Genome Atlas have identified genomic drivers and potentially targetable pathways in gastric cancer, for cancers from the
genome stable
subgroup (often diffuse type gastric cancers), it is not immediately clear which genomic events drive their aggressive phenotype. As previous studies have mainly focused on the protein-coding parts of the genome, which form only 3% of our genome, this project aims to establish the overall importance of mutations in the non-coding genome in cancer.
Vragen over deze functie?
Tanja Hart
Recruitment adviseur
Stel een vraag
Om verder te kunnen gaan, voer gegevens in bij de gemarkeerde velden.
Om verder te kunnen gaan, voer gegevens in bij de gemarkeerde velden.
Sluiten
Annuleren
Versturen
Wat
ga
je doen?
The overarching goal of the project is to develop a powerful genomics pipeline for screening and functional interpretation of such mutations. This should ultimately lead to algorithms that identify relevant non-coding mutations in sequenced genomes of individual cancer patients.
Within this larger multidisciplinary project your contribution lies in the development of organoid models from diffuse type gastric cancers which will be used to determine the functional consequences of non-coding mutations. Mutations will be introduced by CRISPR editing of which the consequences will be further characterized using in vitro and in vivo assay.
Wat
neem
je mee?
We are looking for an enthousiastic post doc with a biological background and a broad interest and experience with organoid development, genomic editing and genomics. You are a team-player with excellent communication skills. You enjoy a challence and have experience with working in a multidisciplinary and internationally oriented work environment.
Wat
bieden
we jou?
- We offer a contract for 1 year that will be extended till september 2026 after successful evaluation.
- In addition to a good basic salary, we offer 8.3% end-of-year bonus and 8% holiday allowance. Do you want to know what you will earn? Then calculate your net salary
- Your pension is accrued with the ABP; VUmc contributes a large part of the premium (70%).
- In addition to excellent accessibility by public transport, we reimburse 75% of your OV travel costs (commuting costs) and also we offer a
- Free and unlimited access to our online learning environment GoodHabitz.
- An active staff association and the Young Amsterdam UMC association, both of which organise fun (sports) activities and events.
- For an overview of all our other terms of employment, see
Waar ga je
werken
?
Within the department of Medical Oncology, the laboratory of dr. S. Derks studies the role of the genome of gastric and esophageal adenocarcinoma and the interaction with the tumor micro-environment at a clinical and preclinical level in gastro-esophageal cancer. She closely collaborates with Prof. Hanneke van Laarhoven, upper-GI cancer specialist and head of the department, as well as Prof. Tanja de Gruijl, professor of translational tumor immunology and head the Immunotherapy and Immune monitoring Lab at the Cancer Center.
The research is supervised by dr. Sarah Derks from the department of
at the
and is part of a large research consortium lead by prof. Bas van Steensel and Prof. Emile Voest from the Dutch Cancer Institute. You will work in multidisciplinary team of scientists from different research institutes. At Amsterdam UMC you will work in a young and dynamic team that works on the interface between clinical and fundamental research.
The culture is open and cooperation generally low key. Moreover, we strive for equal opportunities for everyone. This means that there is room for everyone's culture, origin, ideas and creativity.
Wat kun je
verwachten
?
Een baan in onze prachtige hoofdstad
Werken bij de meest favoriete werkgever in de zorg (intermediair 2021)
Alle collega's hebben hetzelfde doel: bijdragen aan de zorg voor morgen
Wij zorgen niet alleen voor onze patiënten, maar ook voor jou
Samenwerking kenmerkt zich door onderling vertrouwen en interesse voor elkaar
Er is ruimte voor ontplooiing, verdieping en verbreding van je kennis
Amsterdam UMC innoveert continu, je moet dus om kunnen gaan met verandering
We bestaan uit twee locaties, maar er rijdt een pendelbus die deze locaties met elkaar verbindt.
Een volle agenda, want onze personeelsvereniging organiseert veel leuke activiteiten
Het verhaal van Amsterdam UMC
Bekijk de video’s en leer meer over onze organisatie
Amsterdam UMC
Tulp
Verpleegkundige visie
Laten we kennis maken
For more information about this position please contact
dr. Sarah Derks
via
For more information about the application process please contact
Tanja Hart
, Recruitment adviser, via
or via
06-21603178.
A reference check, screening and hiring test may be part of the procedure. Read
whether this also applies to you. If you join us, we ask for a VOG (Certificate of Good Conduct).
Acquisition in response to this vacancy is not appreciated.
Deze vacatures vind je misschien ook leuk
meer...Meer vacatures van Amsterdam Umc